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The reported prevalence of a single gene (monogenic) or two or more genes (polygenic) causes of the disease was high in these cohorts. Prior studies attempted to uncover the genetic basis of hypercholesterolemia included people clinically diagnosed or referred to lipid clinics due to their raised or abnormal levels of blood fats. Both genetic and lifestyle factors are known to predispose a person to hypercholesterolemia. genetics postdoc openings in the lab of Iftikhar Kullo at Mayo Clinic. He has been continuously funded by the NIH since 2003 and is a Principal Investigator in the NHGRI’s eMERGE and PRIMED consortia. Join us for this Mayo Clinic SkillBridge Virtual Information Session on August 31. 'Increased genetic testing and population-scale genomics may help to identify patients in this category who otherwise would go undetected. Kullo heads the Atherosclerosis and Lipid Genomics Laboratory, chairs the Cardiovascular Genomics Task Force and directs the Early Atherosclerosis and Familial Hypercholesterolemia Clinics at Mayo Clinic. Iftikhar Kullo is a Professor of Medicine at Mayo Clinic Rochester, MN. adults have an elevated cholesterol level, with only half on a lipid-lowering treatment. 'In our study, we found more than 50 of the people with disease-causing variants did not meet the clinical criteria for familial hypercholesterolemia,' says Iftikhar Kullo, M.D, a Mayo Clinic cardiologist. It is a significant risk factor for atherosclerotic cardiovascular disease. Hypercholesterolemia is a disease that affects how the body processes cholesterol, the waxy substance found in the blood. (I ’94, CV ’99, CLRSH ’06), and colleagues received a five-year, 5. "Increased genetic testing and population-scale genomics may help to identify patients in this category who otherwise would go undetected." Dr. "In our study, we found more than 50% of the people with disease-causing variants did not meet the clinical criteria for familial hypercholesterolemia," says Iftikhar Kullo, M.D, a Mayo Clinic cardiologist. It also may have implications for the clinical management of patients diagnosed with high cholesterol due to a genetic disorder, or familial hypercholesterolemia. In a new study published in NPJ Genomic Medicine, Mayo Clinic researchers found that genetic testing may help identify patients with high cholesterol, or hypercholesterolemia.